In the second half of the twentieth century, the medical community adopted the scientific method as a basis for practice. It seemed that after thousands of years the way was paved for a regulated process: from the laboratory through the clinical trial to the patient's bed. But it soon became clear that the road is neither straight nor continuous. Clinical research only offers unequivocal answers in a few cases. The balance between benefit and risk does not end with a statistical calculation; A significant part of the consideration of the factors that determine the change of medical practice is based on values, worldview and interests. Many factors are involved in the path leading from the laboratory to the patient: scientists, doctors, pharmaceutical and technology companies, politicians, regulators, and at the end of the path stand the patients themselves. Each of these factors uses the means at its disposal to influence the final result - the diagnosis, treatment and follow-up of the patient. The path of progress from the laboratory to the patient is also not continuous: sometimes the intervals between steps are large, sometimes sudden jumps occur after a prolonged period of slowing down and even stopping. Scientific and clinical research depends on the initiative, skills and determination of the researchers, and not a little on coincidences and has no fixed timetables. This book is dedicated to revealing the evolution of medical practice, to identifying fundamental changes in practice and to describing the winding way in which they were accepted and assimilated into the body of medical knowledge and the mutual relationship between the doctor and the patient.

In October 2018, results of a randomized controlled trial showed an excess mortality mainly from cancer, among “healthy” people over the age of 70 who took aspirin, in contrast to many clinical studies previously published. This event was another record in the crisis in scientific medicine that has been unfolding before our eyes in recent decades. In this book the author tries to trace the causes of the shocks that afflict the medical knowledge base, and to offer solutions to strengthen and stabilize it. This book includes four parts. The first part discusses aspirin as a test case for development of clinical research. The second part is devoted to a discussion of the seven foundations of modern clinical research while revealing the pros and cons of each and their relative contribution to the pursuit of scientific truth. In the third part, five groundbreaking discoveries are examined. In each of them, the process that led to the discovery is deciphered, emphasizing the findings making clinical research, on the way from bench to bedside, redundant. In the fourth part the author exposes the rules of the competition among scientist, and determines its impact on the conduct of research and its results.

Dr. Mozes presents a reflection of his own personal 25-year journey through the fields of clinical practice, clinical epidemiology, and history and philosophy of medicine. His journey passes through 20 stations. Most of the chapters deal with problems that are at the focus of contemporary public debate, such as cholesterol and heart disease, screening for early detection of breast cancer, hormone replacement therapy to treat menopause symptoms, hypertension, diabetes, asthma, vaccination, obesity and bariatric surgery, depression and dementia. At the same time Mozes tries to open a skylight on the personal experiences, motives and desires that drove him to delve into the various topics, and select his particular point of view. "Benjamin Mozes easily refutes many prejudices, touching upon the connections between fears, motivations, beliefs and anxieties, while being attentive to the state of the contemporary man - lending a wise and compassionate ear to patients." (from a review by Ariel Hirschfeld).

Scientific investigation is a cognitive activity, aimed at revealing the truth of nature. Politics is an activity of intent, aimed at realizing specific values derive from subjective judgment. Political activity by scientists is a necessity arising out of the bitter competition over resources. Uncontrolled competition may endanger the ability of science to realize its aims, and will consequently undermine the trust of the society on which its very existence is based. The synthesis between science and politics depends on the interrelationship between daring and humility. Daring is the basis of the drive towards vigorous effort to expose the truth of nature. Humility is the origin of self-discipline and cooperation between individuals. The premise of this book is that recognition of the narrative behind scientific achievements is vital for understanding the scientific enterprise. Besides theoretical discussion the book depicts and interprets case histories relating to the conflict between politics and science: among them, the notebooks of Pasteur, the land of Darwin, the double helix, the understanding of aspirin, lithium and bipolar disorder, and the association between autism and immunization.

The Truth of Scientific Medicine is an attempt to deal with one of the crucial problems in modern medicine: the rapid rate of exchange of truths serving as the foundation of medical practice. Unstable truths are a source of skepticism and concern among many physicians. They are also one of the main reasons for the crisis undermining the trust between patient and physician. The quest for the truth in modern medicine passes through the six core concepts of scientific truth: paradigms, methods, borders, criteria, interpretation and inference. The author deliberates each of these concepts through concrete examples at three levels: the historical, the theoretical and the political. The issues serving as the basis of the discussion are of concern to the medical world, and appear at the core of professional and sometimes the public debate: management of coronary heart disease, treatment of bronchial asthma, hormone replacement in menopausal women, early detection of breast cancer, drug therapy for diabetes, conventional vs. alternative medicine.

The book The Truth of Scientific Medicine tries to cope with one of the central problems of modern medicine: the quick pace in which the truths in the base of medicine practice are changed. Unstable truths are the reason for doubts and fears among many who practice medicine. Furthermore, they are one of the main reasons for the credibility crisis between doctor and patient.