The book deals with basic principles and concepts, the scope of the phenomenon of iatrogenic damage, and the development of risk management practices in medicine and organizational safety culture, emphasizing human and organizational factors, legal and safety aspects, risk management processes in medical organizations, partnership with patients for assuring patient safety, evaluation and measurement, and current trends. In addition, a large chapter is devoted to risk management during the coronavirus pandemic, during which the inexhaustible capabilities of the Israeli health care system were manifested. The target audiences for this book are doctors, nurses, pharmacists, psychologists, occupational therapists, physiotherapists, managers, and all those working in health care institutions who are directly or indirectly involved in patient care.